Hi sir,
I think the important thing about designing a page is quality, so what about clean, organized, well commented and best practice design.
Those days mobiles are used frequently, I think mobile first design would be great fits all screens.
High quality design compatible with all browsers would be more beneficial for your design, visitors could use any browser and got the same design .
But I want to ask you about work, do you use any frameworks like bootstrap, foundation, etc.
I could deliver a page in 2 days full responsive design.
I'm available +40 hour per week so feel free to contact me if you want to ask about anything.